These numbers tell how many of each type of white blood cell are present and whether or not they appear normal. White blood cells help fight infection. It is important to know whether the count is low, normal, or high. White blood cell numbers can increase in response to inflammation and infection. In leukemia, a cancer of the blood system, the numbers of white blood cells are increased or their appearance is abnormal. White blood cell numbers can decrease with severe infection or with bone marrow disease.